Synthesis and Characterization of Privileged Monodentate Phosphoramidite Ligands and Chiral Bronsted Acids Derived from D-Mannitol

被引：5

作者：

Al-Majid, Abdullah Mohammed A. ^{[1
]}

Barakat, Assem ^{[1
]}

Mabkhot, Yahia Nasser ^{[1
]}

Islam, Mohammad Shahidul ^{[1
]}

机构：

[1] King Saud Univ, Dept Chem, Fac Sci, Riyadh 11451, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 03期

关键词：

phosphoramidite; Bronsted acid; D-mannitol; ASYMMETRIC HYDROGENATION; CONJUGATE ADDITION; ENANTIOSELECTIVE HYDROSILYLATION; ALLYLIC SUBSTITUTION; PHOSPHORIC-ACID; BOND; CYCLOADDITION; MECHANISM; TRIMETHYLENEMETHANE; DERIVATIVES;

D O I：

10.3390/ijms13032727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The synthesis of several novel chiral phosphoramidite ligands (L1-L8) with C-2 symmetric, pseudo C-2 symmetric secondary amines and chiral Bronsted acids 1a,b has been achieved. These chiral auxiliaries were obtained from commercially available D-mannitol, and secondary amines in moderate to excellent yields. Excellent diastereoselectivites of ten chiral auxiliaries were obtained. The chiral phosphoramidite ligands and chiral Bronsted acids were fully characterized by spectroscopic methods.

引用

页码：2727 / 2743

页数：17

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