Concise syntheses of meridianins by carbonylative alkynylation and a four-component pyrimidine synthesis

被引：189

作者：

Karpov, AS ^{[1
]}

Merkul, E ^{[1
]}

Rominger, F ^{[1
]}

Müller, TJJ ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 42期

关键词：

C-C coupling; carbonylation; heterocycles; multicomponent reactions; natural products;

D O I：

10.1002/anie.200501703

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) In one go: (Hetero)aryl iodides, alkynes, carbon monoxide, and amidines can be assembled in a consecutive four-component reaction to give pyrimidines by a sequence of carbonylative alkynylation and cyclocondensation. Carbonylative alkynylation also is the key step in the two-step syntheses of meridianins and meridianin derivatives. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6951 / 6956

页数：6

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