High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

被引：180

作者：

Tsai, Chih-Pin ^{[1
]}

Hung, Yann ^{[1
]}

Chou, Yi-Hsin ^{[2
]}

Huang, Dong-Ming ^{[3
]}

Hsiao, Jong-Kai ^{[4
,5
]}

Chang, Chen ^{[2
]}

Chen, Yao-Chang ^{[6
]}

Mou, Chung-Yuan ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[3] Natl Hlth Res Inst, Ctr Nanomed Res, Miaoli County 350, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei, Taiwan

[5] Coll Med, Taipei, Taiwan

[6] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan

来源：

SMALL | 2008年 / 4卷 / 02期

关键词：

fluorescent probes; imaging; magnetic properties; mesoporous materials; nanorods;

D O I：

10.1002/smll.200700457

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.

引用

页码：186 / 191

页数：6

共 31 条

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