High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

被引:180
作者
Tsai, Chih-Pin [1 ]
Hung, Yann [1 ]
Chou, Yi-Hsin [2 ]
Huang, Dong-Ming [3 ]
Hsiao, Jong-Kai [4 ,5 ]
Chang, Chen [2 ]
Chen, Yao-Chang [6 ]
Mou, Chung-Yuan [1 ]
机构
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[2] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
[3] Natl Hlth Res Inst, Ctr Nanomed Res, Miaoli County 350, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei, Taiwan
[5] Coll Med, Taipei, Taiwan
[6] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan
关键词
fluorescent probes; imaging; magnetic properties; mesoporous materials; nanorods;
D O I
10.1002/smll.200700457
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.
引用
收藏
页码:186 / 191
页数:6
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