2-azetidinone cholesterol absorption inhibitors: Increased potency by substitution of the C-4 phenyl ring

被引：24

作者：

Vaccaro, WD ^{[1
]}

Sher, R ^{[1
]}

Davis, HR ^{[1
]}

机构：

[1] Schering Plough Corp, Inst Res, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(98)00073-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SAR studies directed towards the optimization of 2-azetidinone cholesterol absorption inhibitors led to the discovery of 11a, the most potent cholesterol absorption inhibitor yet identified. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1429 / 1437

页数：9

共 13 条

[11] HYPOCHOLESTEROLEMIC ACTIVITY OF A NOVEL INHIBITOR OF CHOLESTEROL ABSORPTION, SCH-48461
SALISBURY, BG
DAVIS, HR
BURRIER, RE
BURNETT, DA
BOYKOW, G
CAPLEN, MA
CLEMMONS, AL
COMPTON, DS
HOOS, LM
MCGREGOR, DG
SCHNITZERPOLOKOFF, R
SMITH, AA
WEIG, BC
ZILLI, DL
CLADER, JW
SYBERTZ, EJ
[J]. ATHEROSCLEROSIS, 1995, 115 (01) : 45 - 63
[12] VACCARO W, 1995, 210 ACS NAT M CHIC I
[13] Sugar-substituted 2-azetidinones as cholesterol absorption inhibitors
Vaccaro, WD
Sher, R
Davis, HR
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (01) : 35 - 40

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