Transcription factor PITX3 gene in Parkinson's disease

被引：32

作者：

Le, Weidong ^{[1
]}

Deanne Nguyen ^{[1
]}

Lin, Xiyao Wendy ^{[1
]}

Rawal, Pawan ^{[1
]}

Huang, Maosheng ^{[2
]}

Ding, Yujian ^{[3
]}

Xie, Wenjie ^{[1
]}

Deng, Hao ^{[4
,5
]}

Jankovic, Joseph ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[3] Shanghai Jiao Tong Univ, Inst Neurol, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China

[4] Cent S Univ, Ctr Med Expt, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

[5] Cent S Univ, Dept Neurol, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 04期

关键词：

Single nucleotide polymorphisms; Dopaminergic neurons; Substantia nigra; Neurogenetics; DOPAMINERGIC-NEURONS; MICE;

D O I：

10.1016/j.neurobiolaging.2009.03.015

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

PITX3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. Recent reports suggest that single nucleotide polymorphisms (SNP) in the gene may be associated with Parkinson's disease (PD). To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls. Our data show that the substitutions of C/T in SNP1 and A/T in SNP2 are significantly higher in PD, and this finding is even more robust in young onset and familial PD as compared with age-matched healthy controls. Our findings indicate that PITX3 may play a role in the pathogenesis of PD. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：750 / 753

页数：4

共 15 条

[11] Etiopathogenesis of Parkinson Disease: A New Beginning? [J].