The highly similar Arabidopsis homologs of trithorax ATX1 and ATX2 encode proteins with divergent biochemical functions

被引：173

作者：

Saleh, Abdelaty ^{[1
,2
]}

Alvarez-Venegas, Raul ^{[1
,3
]}

Yilmaz, Mehtap ^{[1
,4
]}

Oahn-Le ^{[1
,5
]}

Hou, Guichuan ^{[1
,5
]}

Sadder, Monther ^{[1
,6
]}

Al-Abdallat, Ayed ^{[1
,6
]}

Xia, Yuannan ^{[7
]}

Lu, Guoqinq ^{[8
]}

Ladunga, Istvan ^{[9
,10
]}

Avramova, Zoya ^{[1
]}

机构：

[1] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA

[2] N Carolina State Univ, Raleigh, NC 27606 USA

[3] Ctr Invest & Estudios Avanzados, Dept Genet Engn, Guanajuato 36281, Mexico

[4] Boston Univ, Dept Cell & Mol Biol, Boston, MA 02215 USA

[5] Appalachian State Univ, Microscopy Facil, Boone, NC 28608 USA

[6] Univ Jordan, Fac Agr, Amman 11942, Jordan

[7] Univ Nebraska, Ctr Biotechnol, Genom Core Res Facil, Lincoln, NE 68588 USA

[8] Univ Nebraska, Dept Biol, Omaha, NE 68182 USA

[9] Univ Nebraska, Ctr Biotechnol, Lincoln, NE 68588 USA

[10] Univ Nebraska, Dept Stat, Lincoln, NE 68588 USA

来源：

PLANT CELL | 2008年 / 20卷 / 03期

关键词：

D O I：

10.1105/tpc.107.056614

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene duplication followed by functional specialization is a potent force in the evolution of biological diversity. A comparative study of two highly conserved duplicated genes, ARABIDOPSIS TRITHORAX- LIKE PROTEIN1 (ATX1) and ATX2, revealed features of both partial redundancy and of functional divergence. Although structurally similar, their regulatory sequences have diverged, resulting in distinct temporal and spatial patterns of expression of the ATX1 and ATX2 genes. We found that ATX2 methylates only a limited fraction of nucleosomes and that ATX1 and ATX2 influence the expression of largely nonoverlapping gene sets. Even when coregulating shared targets, ATX1 and ATX2 may employ different mechanisms. Most remarkable is the divergence of their biochemical activities: both proteins methylate K4 of histone H3, but while ATX1 trimethylates it, ATX2 dimethylates it. ATX2 and ATX1 provide an example of separated K4 di from K4 trimethyltransferase activity.

引用

页码：568 / 579

页数：12

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