Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury

被引：117

作者：

Baumann, CR

Stocker, R

Imhof, HG

Trentz, O

Hersberger, M

Mignot, E

Bassetti, CL

机构：

[1] Univ Spital Zurich, Dept Neurol, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Intens Care Med, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Dept Neurosurg, CH-8091 Zurich, Switzerland

[4] Univ Zurich Hosp, Dept Traumat Surg, CH-8091 Zurich, Switzerland

[5] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland

[6] Stanford Ctr Narcolepsy, Palo Alto, CA USA

来源：

NEUROLOGY | 2005年 / 65卷 / 01期

关键词：

D O I：

10.1212/01.wnl.0000167605.02541.f2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.

引用

页码：147 / 149

页数：3

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