Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain

被引：33

作者：

Ariumi, Y ^{[1
]}

Kaida, A ^{[1
]}

Hatanaka, M ^{[1
]}

Shimotohno, K ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 287卷 / 02期

关键词：

AIDS; HIV-1; Tat; p53; NF-kappa B; CBP/p300; replication;

D O I：

10.1006/bbrc.2001.5626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) Tat repressed the p53-dependent gene expression through its C-terminal domain of Tat (amino acid residues 73-86) independent of the involvement of NF-kappaB and coactivator CBP/p300. Although Tat did not directly bind to p53, this repression required the N-terminal domain of p53. In contrast, Tat and p53 cooperated in the activation of HIV-1 gene expression. Thus, the crosstalk between Tat and p53 may be linked with cellular transformation by HIV-1 infection or activation of HIV-1 replication. (C) 2001 Academic Press.

引用

收藏

页码：556 / 561

页数：6

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