Haptoglobin Genotype and Its Role in Diabetic Cardiovascular Disease

被引：50

作者：

Costacou, Tina ^{[1
]}

Levy, Andrew P. ^{[2
]}

机构：

[1] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA

[2] Technion Israel Inst Technol, Technion Fac Med, Haifa, Israel

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2012年 / 5卷 / 04期

关键词：

Haptoglobin genotype; Cardiovascular disease; Diabetes; VITAMIN-E SUPPLEMENTATION; CORONARY-ARTERY CALCIFICATION; HEMOGLOBIN SCAVENGER RECEPTOR; MIDDLE-AGED INDIVIDUALS; LOW-DENSITY-LIPOPROTEIN; ACUTE-PHASE PROTEINS; BETA-CAROTENE; IN-VITRO; RISK-FACTOR; VASCULAR COMPLICATIONS;

D O I：

10.1007/s12265-012-9361-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the development of cardiovascular disease among individuals with diabetes mellitus.

引用

页码：423 / 435

页数：13

共 112 条

[61] Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque [J].

Levy, Andrew P. ;

Levy, Joanne E. ;

Kalet-Litman, Shiri ;

Miller-Lotan, Rachel ;

Levy, Nina S. ;

Asaf, Roy ;

Guetta, Julia ;

Yang, Chingwen ;

Purushothaman, K. Raman ;

Fuster, Valentin ;

Moreno, Pedro R. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (01) :134-140

[62] The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes [J].

Levy, AP ;

Gerstein, HC ;

Miller-Lotan, R ;

Rather, R ;

McQueen, M ;

Lonn, E ;

Pogue, J .

DIABETES CARE, 2004, 27 (11) :2767-2767

[63] The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women [J].

Levy, AP ;

Friedenberg, P ;

Lotan, R ;

Ouyang, P ;

Tripputi, M ;

Higginson, L ;

Cobb, FR ;

Tardif, JC ;

Bittner, V ;

Howard, BV .

DIABETES CARE, 2004, 27 (04) :925-930

[64] Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes: The strong heart study [J].

Levy, AP ;

Hochberg, I ;

Jablonski, K ;

Resnick, HE ;

Lee, ET ;

Best, L ;

Howard, BV .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (11) :1984-1990

[65] Inflammation in Atherosclerosis From Pathophysiology to Practice [J].

Libby, Peter ;

Ridker, Paul M. ;

Hansson, Goran K. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (23) :2129-2138

[66] Association of haptoglobin genotype and common cardiovascular risk factors with the amount of iron in atherosclerotic carotid plaques [J].

Lioupis, Christos ;

Barbatis, Calypso ;

Drougou, Aggeliki ;

Koliaraki, Vasiliki ;

Mamalaki, Avgi ;

Klonaris, Christos ;

Georgopoulos, Sotirios ;

Andrikopoulos, Vasilios ;

Bastounis, Elias .

ATHEROSCLEROSIS, 2011, 216 (01) :131-138

[67]

Lonn E, 2005, JAMA-J AM MED ASSOC, V293, P1338, DOI 10.1001/jama.293.11.1338

[68]

Marre M, 1999, DIABETES CARE, V22, pB53

[69] Structure-function analysis of the antioxidant properties of haptoglobin [J].

Melamed-Frank, M ;

Lache, O ;

Enav, BI ;

Szafranek, T ;

Levy, NS ;

Ricklis, RM ;

Levy, AP .

BLOOD, 2001, 98 (13) :3693-3698

[70] PROGNOSTIC-SIGNIFICANCE OF MICROALBUMINURIA IN INSULIN-DEPENDENT DIABETES-MELLITUS - A 23-YEAR FOLLOW-UP-STUDY [J].

MESSENT, JWC ;

ELLIOTT, TG ;

HILL, RD ;

JARRETT, RJ ;

KEEN, H ;

VIBERTI, G .

KIDNEY INTERNATIONAL, 1992, 41 (04) :836-839

← 2 3 4 5 6 7 8 9 10 11 →