Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective

被引：88

作者：

Kent, C ^{[1
]}

机构：

[1] SBC GLOBAL, La Jolla, CA 92037 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2005年 / 1733卷 / 01期

基金：

美国国家卫生研究院;

关键词：

phosphatidylcholine; CDP-choline; phosphocholine; choline kinase; cytidylyltransferase;

D O I：

10.1016/j.bbalip.2004.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylcholine is a prominent constituent of eukaryotic and some prokaryotic membranes. This Perspective focuses on the two enzymes that regulate its biosynthesis, choline kinase and CTP:phosphocholine cytidylyltransferase. These enzymes are discussed with respect to their molecular properties, isoforms, enzymatic activities, and structures, and the possible molecular mechanisms by which they participate in replation of phosphatidylcholine levels in the cell. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：53 / 66

页数：14

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