From neurite to nerve terminal: Induction of presynaptic differentiation by target-derived signals

被引:25
作者
Dai, ZS
Peng, HB
机构
[1] Dept. Cell Biol. Anat. Curriculum N., Univ. of N. Carolina at Chapel Hill, Chapel Hill
来源
SEMINARS IN THE NEUROSCIENCES | 1996年 / 8卷 / 02期
基金
美国国家卫生研究院;
关键词
synapse; synaptogenesis; neuromuscular junction (NMJ); presynaptic; development;
D O I
10.1006/smns.1996.0013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The developing neuromuscular junction provides a simple system for understanding the cellular and molecular events that transform a growth cone into a nerve terminal. Molecules on the surface and within the extracellular matrix of the skeletal muscle cell provide cues for presynaptic differentiation which culminates in the development of presynaptic specializations. Growth factors bound to the heparan-sulfate proteoglycan on the muscle surface have been implicated as signals for the induction of these specializations. Upon reaching the target, the nerve may secrete a molecule to cause the local release of these factors, which then activate receptor tyrosine kinases on the neuronal membrane. This process may lend to the assembly of a cytoskeletal specialization to effect the clustering of synaptic vesicles and the organization of the presynaptic membrane.
引用
收藏
页码:97 / 106
页数:10
相关论文
共 89 条
[71]   ESSENTIAL FUNCTIONS OF SYNAPSIN-I AND SYNAPSIN-II IN SYNAPTIC VESICLE REGULATION [J].
ROSAHL, TW ;
SPILLANE, D ;
MISSLER, M ;
HERZ, J ;
SELIG, DK ;
WOLFF, JR ;
HAMMER, RE ;
MALENKA, RC ;
SUDHOF, TC .
NATURE, 1995, 375 (6531) :488-493
[72]   PROTEOGLYCANS AS MODULATORS OF GROWTH-FACTOR ACTIVITIES [J].
RUOSLAHTI, E ;
YAMAGUCHI, Y .
CELL, 1991, 64 (05) :867-869
[73]   POLYSIALIC ACID ON THE SURFACE OF AXONS REGULATES PATTERNS OF NORMAL AND ACTIVITY-DEPENDENT INNERVATION [J].
RUTISHAUSER, U ;
LANDMESSER, L .
TRENDS IN NEUROSCIENCES, 1991, 14 (12) :528-532
[75]   MOLECULAR HETEROGENEITY OF BASAL LAMINAE - ISOFORMS OF LAMININ AND COLLAGEN-IV AT THE NEUROMUSCULAR-JUNCTION AND ELSEWHERE [J].
SANES, JR ;
ENGVALL, E ;
BUTKOWSKI, R ;
HUNTER, DD .
JOURNAL OF CELL BIOLOGY, 1990, 111 (04) :1685-1699
[76]   RE-INNERVATION OF MUSCLE-FIBER BASAL LAMINA AFTER REMOVAL OF MYOFIBERS - DIFFERENTIATION OF REGENERATING AXONS AT ORIGINAL SYNAPTIC SITES [J].
SANES, JR ;
MARSHALL, LM ;
MCMAHAN, UJ .
JOURNAL OF CELL BIOLOGY, 1978, 78 (01) :176-198
[77]  
SWENARCHUK LE, 1990, DEVELOPMENT, V110, P51
[78]   PRESYNAPTIC LOCALIZATION OF OMEGA-CONOTOXIN-SENSITIVE CALCIUM CHANNELS AT THE FROG NEUROMUSCULAR-JUNCTION [J].
TARELLI, FT ;
PASSAFARO, M ;
CLEMENTI, F ;
SHER, E .
BRAIN RESEARCH, 1991, 547 (02) :331-334
[79]  
TOSNEY KW, 1986, DEV BIOL, V114, P468
[80]   AGRIN IS A HEPARAN-SULFATE PROTEOGLYCAN [J].
TSEN, G ;
HALFTER, W ;
KROGER, S ;
COLE, GJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :3392-3399