Microwave assisted solid-phase synthesis of trisubstituted 2-(2,6-purin-9-yl)acetamides

被引：8

作者：

Austin, RE

Waldraff, C

Al-Obeidi, F

机构：

[1] ACTC, Aventis Combinatorial Technol Ctr, Tucson, AZ 85737 USA

[2] Bayer CropSci, Hit Discovery Grp, D-65926 Frankfurt, Germany

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期

关键词：

D O I：

10.1016/j.tetlet.2005.02.130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the course of developing a method for the parallel synthesis of purin-9-yl-acetamides, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2873 / 2875

页数：3

相关论文

共 18 条

[1] Microwave-Assisted Solid-phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis [J].

Al-Obeidi, Fahad ;

Austin, Richard E. ;

Okonya, John F. ;

Bond, Daniel R. S. .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (05) :449-460

[2] Microwave-assisted solid-phase synthesis (MASS) of 2,6,9-trisubstituted purines [J].

Austin, RE ;

Okonya, JF ;

Bond, DRS ;

Al-Obeidi, F .

TETRAHEDRON LETTERS, 2002, 43 (35) :6169-6171

[3] Traceless solid-phase synthesis of 2,6,9-trisubstituted purines from resin bound 6-thiopurines [J].

Brun, V ;

Legraverend, M ;

Grierson, DS .

TETRAHEDRON, 2002, 58 (39) :7911-7923

[4]

CAMIELA G, 1998, CHEM SOC REV, V27, P213

[5]

CHAN DMC, 1995, ACTA CRYSTALLOGR C, V51, P2386

[6] Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors [J].

Chang, YT ;

Gray, NS ;

Rosania, GR ;

Sutherlin, DP ;

Kwon, S ;

Norman, TC ;

Sarohia, R ;

Leost, M ;

Meijer, L ;

Schultz, PG .

CHEMISTRY & BIOLOGY, 1999, 6 (06) :361-375

[7] Solid supported aryl/heteroaryl C-N cross-coupling reactions. [J].

Combs, AP ;

Saubern, S ;

Rafalski, M ;

Lam, PYS .

TETRAHEDRON LETTERS, 1999, 40 (09) :1623-1626

[8] Novel solid-phase preparation of 2,6,9-trisubstituted purines for combinatorial library generation [J].

Dorff, PH ;

Garigipati, RS .

TETRAHEDRON LETTERS, 2001, 42 (15) :2771-2773

[9] Solution-phase synthesis of 2,6,9-trisubstituted purines [J].

Fiorini, MT ;

Abell, C .

TETRAHEDRON LETTERS, 1998, 39 (13) :1827-1830

[10] Combinatorial synthesis of 2,9-substituted purines. [J].

Gray, NS ;

Kwon, S ;

Schultz, PG .

TETRAHEDRON LETTERS, 1997, 38 (07) :1161-1164