Ultrasound in peptide synthesis .5. Acylation of unprotected amino acids using ultrasound

被引：15

作者：

Anuradha, MV ^{[1
]}

Ravindranath, B ^{[1
]}

机构：

[1] VITTAL MALLYA SCI RES FDN, BANGALORE 560004, KARNATAKA, INDIA

来源：

TETRAHEDRON | 1997年 / 53卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(96)01042-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unprotected amino acids could be readily acylated by sonication with acid anhydrides and activated esters in organic solvents, use of a tertiary base facilitated the reaction in certain cases. The reaction with acetic anhydride has been used to achieve a very convenient one-pot synthesis of the neuropeptide, spaglumic acid N-Carboxyanhydrides of amino acids reacted with other amino acids and dipeptides under these conditions to yield dipeptides and tripeptides Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：1123 / 1130

页数：8

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