Direct resolution of a new antifungal agent, voriconazole (UK-109,496) and its potential impurities, by use of coupled achiral - Chiral high-performance liquid chromatography

被引：30

作者：

Ferretti, R ^{[1
]}

Gallinella, B ^{[1
]}

La Torre, F ^{[1
]}

Zanitti, L ^{[1
]}

机构：

[1] Ist Super Sanita, Lab Chim Farmaco, I-00161 Rome, Italy

来源：

CHROMATOGRAPHIA | 1998年 / 47卷 / 11-12期

关键词：

column liquid chromatography; enantiomer separation; voriconazole (UK-109,496); effect of organic mobile-phase modifier;

D O I：

10.1007/BF02467448

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Coupled achiral-chiral high-performance liquid chromatography (HPLC) with an achiral amino-based column coupled with a chiral amylose-based column has been used for qualitative and quantitative determination of the potential chiral and achiral impurities of Voriconazole (UK-109,496), a new antifungal agent with two stereogenic centres. The effect of the organic mobile-phase modifier, ethanol, was studied. The assay response was linearly dependent on concentration over the range 1.2-40.4 mu g for Voriconazole and 2.5-104.0 ng for the impurities. The limit of detection was 2.5 ng for each analyte.

引用

页码：649 / 654

页数：6

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