Near-Infrared-Absorbing Gold Nanopopcorns with Iron Oxide Cluster Core for Magnetically Amplified Photothermal and Photodynamic Cancer Therapy

被引：120

作者：

Bhana, Saheel ^{[1
]}

Lin, Gan ^{[2
,3
]}

Wang, Lijia ^{[4
]}

Starring, Hunter ^{[1
]}

Mishra, Sanjay R. ^{[4
]}

Liu, Gang ^{[2
,3
]}

Huang, Xiaohua ^{[1
]}

机构：

[1] Univ Memphis, Dept Chem, Memphis, TN 38152 USA

[2] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Fujian Province, Peoples R China

[3] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Fujian Province, Peoples R China

[4] Univ Memphis, Dept Phys, Memphis, TN 38152 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 21期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

iron oxide-gold nanopopcorns; hybrid nanoparticles; magnetic attraction; drug delivery; cancer; photothermal therapy; photodynamic therapy; IN-VIVO; OPTICAL-PROPERTIES; MULTIFUNCTIONAL NANOPARTICLES; CONVERSION EFFICIENCY; NANOSHELLS; NANORODS; NANOCRYSTALS; ABLATION; CELLS; SHAPE;

D O I：

10.1021/acsami.5b02741

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

We present the synthesis and application of a new type of dual magnetic and plasmonic nanostructures for magnetic-field-guided drug delivery and combined photothermal and photodynamic cancer therapy. Near-infrared-absorbing gold nanopopcorns containing a self-assembled iron oxide cluster core were prepared via a seed-mediated growth method. The hybrid nanostructures are superparamagnetic and show great photothermal conversion efficiency (eta = 61%) under near-infrared irradiation. Compact and stable nano complexes for photothermal photodynamic therapy were formed by coating the nanoparticles with near-infrared-absorbing photosensitizer silicon 2,3-naphthalocyannie dihydroxide and stabilization with poly(ethylene glycol) linked with 11-mercaptoundecanoic acid. The nanocomplex showed enhanced release and cellular uptake of the photosensitizer with the use of a gradient magnetic field. In vitro studies using two different cell lines showed that the dual mode photothermal and photodynamic therapy with the assistance of magnetic-field-guided drug delivery dramatically improved the therapeutic efficacy of cancer cells as compared to the combination treatment without using a magnetic field and the two treatment alone. The "three-in-one" nanocomplex has the potential to carry therapeutic agents deep into a tumor through magnetic manipulation and to completely eradicate tumors by subsequent photothermal and photodynamic therapies without systemic toxicity.

引用

页码：11637 / 11647

页数：11

共 63 条

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