Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS

被引：29

作者：

Gobbo, Oliviero L. ^{[1
,2
]}

Wetterling, Friedrich ^{[2
]}

Vaes, Peter ^{[3
]}

Teughels, Stephanie ^{[3
]}

Markos, Farouk ^{[4
]}

Edge, Deirdre ^{[4
]}

Shortt, Christine M. ^{[4
]}

Crosbie-Staunton, Kieran ^{[5
]}

Radomski, Marek W. ^{[1
]}

Volkov, Yuri ^{[5
,6
]}

Prina-Mello, Adriele ^{[5
,6
]}

机构：

[1] Sch Pharm & Pharmaceut Sci, Dublin, Ireland

[2] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

[3] PEPRIC NV, Leuven, Belgium

[4] Natl Univ Ireland Univ Coll Cork, Dept Physiol, Cork, Ireland

[5] Sch Med, Dublin, Ireland

[6] Univ Dublin Trinity Coll, CRANN, Dublin 2, Ireland

来源：

NANOMEDICINE | 2015年 / 10卷 / 11期

关键词：

biodistribution; ICP-MS; MRI; nanomedicine; pEPR; pharmacokinetics; SPION; MAGNETIC NANOPARTICLES; MANGANESE; AGENTS;

D O I：

10.2217/nnm.15.22

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Superparamagnetic iron oxide nanoparticles (SPIONs) may play an important role in nanomedicine by serving as drug carriers and imaging agents. In this study, we present the biodistribution and pharmacokinetic properties of SPIONs using a new detection method, particle electron paramagnetic resonance (pEPR). Materials & methods: The pEPR technique is based on a low-field and low-frequency electron paramagnetic resonance. pEPR was compared with inductively coupled plasma mass spectrometry and MRI, in in vitro and in vivo. Results: The pEPR, inductively coupled plasma mass spectrometry and MRI results showed a good correlation between the techniques. Conclusion: The results indicate that pEPR can be used to detect SPIONs in both preclinical and clinical studies.

引用

页码：1751 / 1760

页数：10

共 28 条

[1] Size-Stable Solid Lipid Nanoparticles Loaded with Gd-DOTA for Magnetic Resonance Imaging [J].

Andreozzi, Erica ;

Wang, Peter ;

Valenzuela, Anthony ;

Tu, Chuqiao ;

Gorin, Fredric ;

Dhenain, Marc ;

Louie, Angelique .

BIOCONJUGATE CHEMISTRY, 2013, 24 (09) :1455-1467

[2] Comparison of Electron Spin Resonance Spectroscopy and Inductively-Coupled Plasma Optical Emission Spectroscopy for Biodistribution Analysis of Iron-Oxide Nanoparticles [J].

Chertok, Beata ;

Cole, Adam J. ;

David, Allan E. ;

Yang, Victor C. .

MOLECULAR PHARMACEUTICS, 2010, 7 (02) :375-385

[3] Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies [J].

Danhier, P. ;

De Preter, G. ;

Boutry, S. ;

Mahieu, I. ;

Leveque, P. ;

Magat, J. ;

Haufroid, V. ;

Sonveaux, P. ;

Bouzin, C. ;

Feron, O. ;

Muller, R. N. ;

Jordan, B. F. ;

Gallez, B. .

CONTRAST MEDIA & MOLECULAR IMAGING, 2012, 7 (03) :302-307

[4] Magnetic Biotransport: Analysis and Applications [J].

Furlani, Edward P. .

MATERIALS, 2010, 3 (04) :2412-2446

[5] Manganese: a new contrast agent for lung imaging? [J].

Gobbo, Oliviero L. ;

Zurek, Magdalena ;

Tewes, Frederic ;

Ehrhardt, Carsten ;

Cremillieux, Yannick .

CONTRAST MEDIA & MOLECULAR IMAGING, 2012, 7 (06) :542-546

[6] Iron oxide-based nanostructures for MRI and magnetic hyperthermia [J].

Hilger, Ingrid ;

Kaiser, Werner A. .

NANOMEDICINE, 2012, 7 (09) :1443-1459

[7] PULSE-TRAIN-DETECTED ELECTRON-SPIN-ECHO ENVELOPE MODULATION [J].

HUBRICH, M ;

HOFFMANN, EC ;

SCHWEIGER, A .

JOURNAL OF MAGNETIC RESONANCE SERIES A, 1995, 114 (02) :271-273

[8] Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats [J].

Jain, Tapan K. ;

Reddy, Maram K. ;

Morales, Marco A. ;

Leslie-Pelecky, Diandra L. ;

Labhasetwar, Vinod .

MOLECULAR PHARMACEUTICS, 2008, 5 (02) :316-327

[9] Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy? [J].

Kateb, Babak ;

Chiu, Katherine ;

Black, Keith L. ;

Yamamoto, Vicky ;

Khalsa, Bhavraj ;

Ljubimova, Julia Y. ;

Ding, Hui ;

Patil, Rameshwar ;

Portilla-Arias, Jose Antonio ;

Modo, Mike ;

Moore, David F. ;

Farahani, Keyvan ;

Okun, Michael S. ;

Prakash, Neal ;

Neman, Josh ;

Ahdoot, Daniel ;

Grundfest, Warren ;

Nikzad, Shouleh ;

Heiss, John D. .

NEUROIMAGE, 2011, 54 :S106-S124

[10] Surface Engineering of Iron Oxide Nanoparticies for Targeted Cancer Therapy [J].

Kievit, Forrest M. ;

Zhang, Miqin .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :853-862

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