First synthesis of 3′-deoxy Lewisx pentasaccharide

被引：9

作者：

Gourmala, C

Zhu, ZY

Luo, Y

Fan, BT

Ghalem, S

Hu, YZ

Zhang, YM

机构：

[1] Ecole Normale Super, Dept Chim, CNRS, UMR 8642, F-75231 Paris, France

[2] Univ Paris 07, CNRS, UMR 7086, ITODYS, F-75005 Paris, France

[3] Univ Tlemcen, Lab Chim Organ Subst Nat & Anal, Tilimsen, Algeria

[4] Zhejiang Univ, ZJU ENS Joint Lab Med Chem, Hangzhou 310031, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 18期

关键词：

D O I：

10.1016/j.tetasy.2005.08.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The total synthesis of 3'-deoxy Lewis(x) pentasaccharide is reported. 4-O-Acetyl-2,6-di-O-benzoyl-3-deoxy-beta-D-Xylo-hexopyranosyl trichloroacetimidate was condensed with a diol of glucosamine to give a disaccharide, which was further fucosylated to a Lewis(x) trisaccharide analogue. Glycosylation of a lactoside diol with this trisaccharide provided a pentasaccharide, which after deprotection, afforded the target pentasaccharide. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3024 / 3029

页数：6

共 29 条

[1] Lex glycosphingolipids-mediated cell aggregation [J].