From the combinatiorial chemistry boom to polymer-supported parallel chemistry: established technologies for drug discovery

被引：17

作者：

Cano, M

Balasubramanian, S

机构：

[1] R&D Ctr, Ferrer Grp, Dept Med Chem, Barcelona 08028, Spain

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

DRUGS OF THE FUTURE | 2003年 / 28卷 / 07期

关键词：

D O I：

10.1358/dof.2003.028.07.857183

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The application of combinational chemistry has been changing since it was first described almost two decades ago. This review highlights relevant innovative ideas using the combinatorial chemistry approach, fodusing on the present and future scope of this technology and its general acceptance among the scientific community. Recent developments include solid-supported reagents, catalysts, scavengers and purification, resin technology (polymer-supported chemistry on monolithic disks); reporter resins for solid-phase organic chemistry; dynamic combinational libraries; natural product-based libraries and chemical genetics; and microreactors.

引用

页码：659 / 678

页数：20

共 155 条

[71]

Huc I, 1997, P NATL ACAD SCI USA, V94, P8272

[72]

Huc I, 1999, EUR J INORG CHEM, P1415

[73] Development and application of a carbonyl-13C-enriched backbone amide linker for solid-phase reaction monitoring [J].