Application of single drop liquid-liquid-liquid microextraction for the determination of fluoroquinolones in human urine by capillary electrophoresis

被引：51

作者：

Gao, Wenhua ^{[1
,2
]}

Chen, Gaopan ^{[1
]}

Chen, Yaowen ^{[2
]}

Zhang, Xiaoshan ^{[2
]}

Yin, Yegao ^{[1
]}

Hu, Zhide ^{[3
]}

机构：

[1] Shantou Univ, Dept Chem, Shantou 515063, Guangdong, Peoples R China

[2] Shantou Univ, Anal & Testing Ctr, Shantou 515063, Guangdong, Peoples R China

[3] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2011年 / 879卷 / 3-4期

关键词：

Single drop liquid-liquid-liquid microextraction; Capillary electrophoresis; Fluoroquinolones; Urine samples; SOLID-PHASE EXTRACTION; LASER-INDUCED FLUORESCENCE; CHICKEN TISSUES; WATER SAMPLES; PK(A) VALUES; CHROMATOGRAPHY; QUINOLONES; CIPROFLOXACIN; SEPARATION; PHARMACOKINETICS;

D O I：

10.1016/j.jchromb.2010.11.040

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and novel method of single drop liquid-liquid-liquid microextraction (SD-LLLME) coupled with capillary electrophoresis (CE) for the determination of six fluoroquinolones (FQs) was developed. The method was eventually applied to extraction and preconcentration of FQs in human urine samples. Good linear relationships were obtained for all analytes in a range of 40-1000 mu g L-1 with the correlation coefficients from 0.9913 to 0.9995. The limit of detections (LODs) varied from 7.4 to 31.5 mu g L-1 at a signal-to-noise (S/N) of 3. The recoveries at two spiking levels were 81.8-104.9% with relative standard deviations <8.3%. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：291 / 295

页数：5

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