Determination of pKa values of active pharmaceutical ingredients

被引：424

作者：

Babic, Sandra ^{[1
]}

Horvat, Alka J. M. ^{[1
]}

Pavlovic, Dragana Mutavdzic ^{[1
]}

Kastelan-Macan, Marija ^{[1
]}

机构：

[1] Univ Zagreb, Fac Chem Engn & Technol, Analyt Chem Lab, Zagreb, Croatia

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2007年 / 26卷 / 11期

关键词：

active pharmaceutical ingredient; capillary electrophoresis; acid dissociation constant; liquid chromatography; potentiometry; spectrophotometry;

D O I：

10.1016/j.trac.2007.09.004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pK(a) values of active pharmaceutical ingredients. (C) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：1043 / 1061

页数：19

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