Determination of residues of enrofloxacin and its metabolite ciprofloxacin in biological materials by capillary electrophoresis

被引：97

作者：

Barrón, D ^{[1
]}

Jiménez-Lozano, E ^{[1
]}

Cano, J ^{[1
]}

Barbosa, J ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2001年 / 759卷 / 01期

关键词：

solid-phase extraction; enrofloxacin; ciprofloxacin;

D O I：

10.1016/S0378-4347(01)00214-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method for the analysis of enrofloxacin and ciprofloxacin in chicken muscle using marbofloxacin as internal standard is proposed. Clean-up and pre-concentration of the samples are effected by solid-phase extraction and determination is carried out by capillary electrophoresis using a photodiode array detector. The calibration graphs are linear for enrofloxacin and ciprofloxacin from 10 to 300 mug/kg. The method recoveries for enrofloxacin and ciprofloxacin are 74 and 54%, respectively. The limit of detection for the two compounds is lower than 25 mug/kg, which allows the detection of positive muscle samples at the required maximum residue limits. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：73 / 79

页数：7

共 23 条

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