Protein interactions with oligo(ethylene glycol) (OEG) self-assembled monolayers: OEG stability, surface packing density and protein adsorption

被引：163

作者：

Li, Lingyan ^{[1
]}

Chen, Shengfu ^{[1
]}

Jiang, Shaoyi ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98105 USA

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2007年 / 18卷 / 11期

关键词：

oligo(ethylene glycol); stability; surface packing density; protein adsorption;

D O I：

10.1163/156856207782246795

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present a study of protein adsorption on oligo(ethylene glycol) (OEG) self-assembled monolayers (SAMs) at a range of OEG surface densities. OEG SAMs were formed in mixed ethanol and water solutions at different assembly temperatures to adjust the packing density of EG(4)-SAMs. These SAMs were characterized using X-ray photoelectron spectroscopy (XPS). Fibrinogen adsorption on these surfaces was measured by a surface plasmon resonance (SPR) sensor at different temperatures. This work is aimed at addressing three important issues for protein-OEG interactions, i.e., (i) OEG stability, (ii) the correlation between OEG surface densities and surface non-fouling properties, and (iii) protein adsorption on OEG surfaces at different temperatures.

引用

页码：1415 / 1427

页数：13

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