Ribosome assembly in eukaryotes

被引：496

作者：

Fromont-Racine, M

Senger, B

Saveanu, C

Fasiolo, F

机构：

[1] Inst Pasteur, CNRS, URA 2171, F-75724 Paris 15, France

[2] CNRS, Inst Biol Mol & Cellulaire, UPR 9002, F-67084 Strasbourg, France

来源：

GENE | 2003年 / 313卷

关键词：

rRNA maturation; nucleolus; regulation; transport; late steps; assembly; PUTATIVE RNA HELICASE; SMALL NUCLEOLAR RIBONUCLEOPROTEIN; NUCLEAR-PORE COMPLEX; TEMPERATURE-SENSITIVE MUTATIONS; TRANSLATION INITIATION-FACTOR; STEADY-STATE LEVELS; SACCHAROMYCES-CEREVISIAE; YEAST HOMOLOG; BINDING PROTEIN; U3; SNORNP;

D O I：

10.1016/S0378-1119(03)00629-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the protein composition of several ribosomal subunit precursors recently characterized in yeast, a total of more than 170 factors are predicted to participate in ribosome biogenesis and the list is still growing. So far the majority of ribosomal factors have been implicated in RNA maturation (nucleotide modification and processing). Recent advances gave insight into the process of ribosome export and assembly. Proteomic approaches have provided the first indications for a ribosome assembly pathway in eukaryotes and confirmed the dynamic character of the whole process. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：17 / 42

页数：26

共 220 条

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