A radiation hybrid map of mouse genes

被引：47

作者：

Hudson, TJ ^{[1
]}

Church, DM

Greenaway, S

Nguyen, H

Cook, A

Steen, RG

Van Etten, WJ

Castle, AB

Strivens, MA

Trickett, P

Heuston, C

Davison, C

Southwell, A

Hardisty, R

Varela-Carver, A

Haynes, AR

Rodriguez-Tome, P

Doi, H

Ko, MSH

Pontius, J

Schriml, L

Wagner, L

Maglott, D

Brown, SDM

Lander, ES

Schuler, G

Denny, P

机构：

[1] MIT, Whitehead Inst, Ctr Genome Res, Cambridge, England

[2] McGill Univ, Ctr Hlth, Montreal Genome Ctr, Montreal, PQ, Canada

[3] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD USA

[4] MRC, UK Mouse Genome Ctr, Oxford, England

[5] Mammalian Genet Unit, Oxford, England

[6] European Mol Biol Lab, European Bioinformat INst, Cambridge, England

[7] Japan Sci & Technol Corp, ERATO, Doi Bioasymmetry Project, Chiba 2617112, Japan

[8] NIA, Genet Lab, NIH, Baltimore, MD 21224 USA

[9] MIT, Dept Biol, Cambridge, MA USA

来源：

NATURE GENETICS | 2001年 / 29卷 / 02期

关键词：

D O I：

10.1038/ng1001-201

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A comprehensive gene-based map of a genome is a powerful tool for genetic studies and is especially useful for the positional cloning and positional candidate approaches. The availability of gene maps for multiple organisms provides the foundation for detailed conserved-orthology maps showing the correspondence between conserved genomic segments, These maps make it possible to use cross-species information in gene hunts and shed light on the evolutionary forces that shape the genome. Here we report a radiation hybrid map of mouse genes, a combined project of the Whitehead Institute/Massachusetts Institute of Technology Center for Genome Research, the Medical Research Council UK Mouse Genome Centre, and the National Center for Biotechnology Information. The map contains 11,109 genes, screened against the T31 RH panel(1) and positioned relative to a reference map containing 2,280 mouse genetic markers(2). It includes 3,658 genes homologous to the human genome sequence(3) and provides a framework for overlaying the human genome sequence to the mouse and for sequencing the mouse genome.

引用

页码：201 / 205

页数：5

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