The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases

被引：356

作者：

Balistreri, Carmela Rita ^{[1
]}

Caruso, Calogero ^{[1
]}

Candore, Giuseppina ^{[1
]}

机构：

[1] Univ Palermo, Dept Pathobiol & Med & Forens Biotechnol, Immunosenescence Grp, I-90134 Palermo, Italy

来源：

MEDIATORS OF INFLAMMATION | 2010年 / 2010卷

关键词：

BODY-MASS INDEX; NECROSIS-FACTOR-ALPHA; TYPE-2; DIABETIC-PATIENTS; NERVOUS-SYSTEM CONTROL; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; ALZHEIMER-DISEASE; PROSTATE-CANCER; KAPPA-B; IMMUNE-RESPONSE;

D O I：

10.1155/2010/802078

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.

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页数：19

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