Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: Four cases

被引：27

作者：

Del Tredici, Kelly ^{[1
]}

Duda, John E. ^{[2
,3
]}

机构：

[1] Univ Ulm, Dept Neurol, Clin Res Ctr, D-89081 Ulm, Germany

[2] Philadelphia VA Med Ctr, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 310卷 / 1-2期

关键词：

Alpha-synuclein; Auerbach plexus; Autonomic nervous system; Axonal; Brainstem; Celiac ganglion; Cognitive dysfunction; Incidental Lewy body disease; Lewy bodies/Lewy neurites; Non-motor symptoms; Parkinson's disease; Submandibular gland; Superior cervical ganglion; Sympathetic trunk; Synucleinopathy; Thyroid gland; AUTONOMIC NERVOUS-SYSTEM; HUMAN ALPHA-SYNUCLEIN; NONMOTOR SYMPTOMS; MOVEMENT-DISORDERS; AXONAL-TRANSPORT; BRAIN PATHOLOGY; BODIES; PLEXUSES; GANGLIA; DEGENERATION;

D O I：

10.1016/j.jns.2011.06.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has received increased attention recently as a possible induction site for Lewy neurodegeneration and a possible source of biopsy material for biomarkers of early Parkinson's disease (PD). Here, we describe LP accumulation within various tissues involving peripheral autonomic nervous system neurons in three PD cases and one case of incidental Lewy body disease. Findings highlight the value of examining pathology within functional neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in the pathophysiology of PD. Published by Elsevier B.V.

引用

页码：100 / 106

页数：7

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