Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort

被引：91

作者：

Adler, Charles H. ^{[1
]}

Connor, Donald J. ^{[2
]}

Hentz, Joseph G. ^{[3
]}

Sabbagh, Marwan N. ^{[2
]}

Caviness, John N. ^{[1
]}

Shill, Holly A. ^{[2
]}

Noble, Brie ^{[3
]}

Beach, Thomas G. ^{[2
]}

机构：

[1] Mayo Clin, Parkinsons Dis & Movement Disorders Ctr, Scottsdale, AZ 85259 USA

[2] Sun Hlth Res Inst, Sun City, AZ USA

[3] Mayo Clin, Biostat Sect, Scottsdale, AZ 85259 USA

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 05期

关键词：

incidental Lewy body disease; Lewy bodies; Parkinson's disease; demential with Lewy bodies; IDIOPATHIC PARKINSONS-DISEASE; PROSPECTIVE BRAIN DONORS; COGNITIVE IMPAIRMENT; LONGITUDINAL EVALUATION; ALPHA-SYNUCLEINOPATHY; MOTOR IMPAIRMENT; DISORDERS; SYSTEM; SIGNS;

D O I：

10.1002/mds.22971

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences. (C) 2010 Movement Disorder Society

引用

页码：642 / 646

页数：5

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