Correlates of cognitive status of old patients with isolated systolic hypertension:: the Syst-Eur vascular dementia project

被引：61

作者：

Seux, ML ^{[1
]}

Thijs, L ^{[1
]}

Forette, F ^{[1
]}

Staessen, JA ^{[1
]}

Birkenhäger, WH ^{[1
]}

Bulpitt, CJ ^{[1
]}

Girerd, X ^{[1
]}

Jääskivi, M ^{[1
]}

Vanhanen, H ^{[1
]}

Kivinen, P ^{[1
]}

Yodfat, Y ^{[1
]}

Vänskä, O ^{[1
]}

Antikainen, R ^{[1
]}

Laks, T ^{[1
]}

Webster, JR ^{[1
]}

Hakamäki, T ^{[1
]}

Lehtomäki, E ^{[1
]}

Lilov, E ^{[1
]}

Grigorov, M ^{[1
]}

Janculova, K ^{[1
]}

Halonen, K ^{[1
]}

Jalonen, PK ^{[1
]}

Kermowa, R ^{[1
]}

Nachev, C ^{[1
]}

Tuomilehto, J ^{[1
]}

机构：

[1] Univ Paris 05, CHU Cochin Port Royal, Hop Broca, Dept Geriatr, F-75013 Paris, France

来源：

JOURNAL OF HYPERTENSION | 1998年 / 16卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

cognitive status; Mini Mental State Examination; isolated systolic hypertension; elderly;

D O I：

10.1097/00004872-199816070-00009

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective To assess cognitive functions and their correlates for a dementia-free cohort of old patients with isolated systolic hypertension. Design Cross-sectional data from the randomization period of the European Trial in Elderly with Systolic Hypertension (Syst-Eur Vascular Dementia Project), Setting Sixteen European countries and Israel. Participants We studied 2252 patients aged 60-100 years (mean 70). Main outcome measures Mini Mental State Examination (MMSE) and Spearman correlation of MMSE scores to demographic data or blood pressure. Results The MMSE was successfully completed for 1474 women and 751 men. The baseline blood pressure averaged 173 +/- 10/86 +/- 6 mmHg (means +/- SD). Median age at which education of patients at school had stopped was 15 years. Men and women who consumed alcohol (28%) had median intakes of 8 and 3 g/day, respectively, The median MMSE score was 29 (range 15-30). The maximum score of 30 was attained by 609 (30%) subjects. Fifty-nine (3%) patients had a MMSE score of 23 or less. The MMSE score decreased with advancing age (r= -0.21, P< 0.001), Both for men and for women, it was positively correlated to the level of education (r = 0.30 and r = 0.32, P < 0.001). For women after adjustment for age and the level of education, the scare was correlated negatively to systolic blood pressure (r = -0.07, P < 0.05) but positively to intake of alcohol (r = 0.06, P< 0.05). Conclusion In a cohort of elderly patients with isolated systolic hypertension, baseline cognitive function measured in terms of the MMSE score was high, probably due to selective recruitment of patients who were not clinically demented. Blood pressure was a weak contributor to cognitive status compared with age and level of education. Baseline cognitive function of women was negatively and independently correlated to systolic blood pressure. I Hypertens 16:963-969 (C) 1998 Lippincott-Raven Publishers.

引用

页码：963 / 969

页数：7

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