Synthesis, Characterization, and Long-Term Stability of Hollow Polymer Nanocapsules with Nanometer-Thin Walls

被引：56

作者：

Dergunov, Sergey A. ^{[1
,2
]}

Kesterson, Katrina ^{[1
,2
]}

Li, Wei ^{[3
]}

Wang, Zhao ^{[3
]}

Pinkhassik, Eugene ^{[1
,2
]}

机构：

[1] Univ Memphis, Inst Nanomat Dev & Innovat INDIUM, Memphis, TN 38152 USA

[2] Univ Memphis, Dept Chem, Memphis, TN 38152 USA

[3] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38163 USA

来源：

MACROMOLECULES | 2010年 / 43卷 / 18期

基金：

美国国家卫生研究院;

关键词：

BLOCK-COPOLYMERS; RADICAL POLYMERIZATION; ORGANIC MATERIALS; VESICLES; CAPSULES; NANOSTRUCTURES; MICROCAPSULES; PERMEABILITY; NANOREACTOR; NANOPORES;

D O I：

10.1021/ma1012418

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hollow polymer nanocapsules are produced by the polymerization within hydrophobic interior of lipid bilayers that act as temporary self-assembled scaffolds. Pore-forming templates are codissolved with monomers in the bilayers to create pores with controlled size and chemical environment. Polymerization was monitored with UV spectroscopy and dynamic light scattering. High-resolution magic angle spinning NMR characterization provided detailed structural information about nanocapsules. Spherical shape was confirmed by electron microscopy. Medium-sized molecules can be entrapped within porous nanocapsules. No release of encapsulated molecules was observed within 240 days.

引用

页码：7785 / 7792

页数：8

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