Microcantilevers and organic transistors: two promising classes of label-free biosensing devices which can be integrated in electronic circuits

被引:16
作者
Cotrone, Serafina [1 ]
Cafagna, Damiana [1 ]
Cometa, Stefania [2 ]
De Giglio, Elvira [1 ]
Magliulo, Maria [1 ]
Torsi, Luisa [1 ]
Sabbatini, Luigia [1 ]
机构
[1] Univ Bari, Dept Chem, I-70126 Bari, Italy
[2] Univ Pisa, Dept Chem & Ind Chem, I-56126 Pisa, Italy
关键词
Organic field-effect transistors (OFETs); Organic electrochemical transistors (OECTs); Microcantilevers; Sensors; Biocompatibility; FIELD-EFFECT TRANSISTORS; THIN-FILM TRANSISTORS; ATOMIC-FORCE MICROSCOPY; CONDUCTING POLYMER MICROELECTRODES; BIOLOGICAL SENSORS; DNA-HYBRIDIZATION; ELECTROCHEMICAL TRANSISTORS; OSTEOBLAST ADHESION; NEURAL-NETWORKS; HYDROGEL FILMS;
D O I
10.1007/s00216-011-5610-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Most of the success of electronic devices fabricated to actively interact with a biological environment relies on the proper choice of materials and efficient engineering of surfaces and interfaces. Organic materials have proved to be among the best candidates for this aim owing to many properties, such as the synthesis tunability, processing, softness and self-assembling ability, which allow them to form surfaces that are compatible with biological tissues. This review reports some research results obtained in the development of devices which exploit organic materials' properties in order to detect biologically significant molecules as well as to trigger/capture signals from the biological environment. Among the many investigated sensing devices, organic field-effect transistors (OFETs), organic electrochemical transistors (OECTs) and microcantilevers (MCLs) have been chosen. The main factors motivating this choice are their label-free detection approach, which is particularly important when addressing complex biological processes, as well as the possibility to integrate them in an electronic circuit. Particular attention is paid to the design and realization of biocompatible surfaces which can be employed in the recognition of pertinent molecules as well as to the research of new materials, both natural and inspired by nature, as a first approach to environmentally friendly electronics.
引用
收藏
页码:1799 / 1811
页数:13
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