Carbon nanohorns functionalized with polyamidoamine dendrimers as efficient biocarrier materials for gene therapy

被引：57

作者：

Guerra, Javier ^{[1
,2
]}

Antonia Herrero, M. ^{[1
]}

Carrion, Blanca ^{[2
]}

Perez-Martinez, Francisco C. ^{[2
]}

Lucio, Maribel ^{[1
]}

Rubio, Noelia ^{[1
]}

Meneghetti, Moreno ^{[3
]}

Prato, Maurizio ^{[4
,5
]}

Cena, Valentin ^{[2
,6
]}

Vazquez, Ester ^{[1
]}

机构：

[1] Univ Castilla La Mancha, Fac Quim IRICA, Dept Quim Organ, E-13071 Ciudad Real, Spain

[2] NanoDrugs SL, Albacete 02006, Spain

[3] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy

[4] Univ Trieste, Ctr Excellence Nanostruct Mat CENMAT, I-34127 Trieste, Italy

[5] Univ Trieste, Italian Interuniv Consortium Mat Sci & Technol, Dipartimento Sci Farmaceut, INSTM Unit Trieste, I-34127 Trieste, Italy

[6] Univ Castilla La Mancha, CSIC, Unidad Asociada Neurodeath, Albacete 02006, Spain

来源：

CARBON | 2012年 / 50卷 / 08期

关键词：

POLY(AMIDOAMINE) DENDRIMERS; ENCAPSULATED NANOPARTICLES; CARBOSILANE DENDRIMERS; IN-VITRO; DELIVERY; NANOTUBES; TOXICITY; BARRIERS; SERIES;

D O I：

10.1016/j.carbon.2012.02.050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Carbon nanohorns are suitable platforms for use in biological applications. Their high surface areas allow the incorporation of molecular entities, such as polyamidoamine dendrimers. In this work, we report the synthesis, structural characterization and biological data of new hybrid systems of carbon nanohorns that hold polyamidoamine dendrimers. One of these derivatives has been employed as an agent for gene delivery. The system is able to release interfering genetic material diminishing the levels of a house-keeping protein and a protein directly involved in prostate cancer development. Importantly, this hybrid material is also far less toxic than the corresponding free dendrimer. These results allow us to conclude that these nanomaterials can be exploited as useful non-viral agents for gene therapy. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2832 / 2844

页数：13

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