Molecular transporter between polymer platforms: Highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports

被引：32

作者：

Fumoto, M

Hinou, H

Matsushita, T

Kurogochi, M

Ohta, T

Ito, T

Yamada, K

Takimoto, A

Kondo, H

Inazu, T

Nishimura, SI ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Res Ctr Glycosci, Glycochemosynth Team, Sapporo, Hokkaido 0628517, Japan

[2] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido 0010021, Japan

[3] Res Assoc Biotechnol, Minato Ku, Tokyo 1050003, Japan

[4] Shionogi & Co Ltd, Chuo Ku, Osaka 5410045, Japan

[5] Hitachi High Technol Co, Minato Ku, Tokyo 1058717, Japan

[6] Sch Engn, Dept Appl Chem, Kanagawa 2591292, Japan

[7] Inst Glychotechnol, Kanagawa 2591292, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 17期

关键词：

enzymes; glycopeptides; polymers; solid-phase synthesis; synthetic methods;

D O I：

10.1002/anie.200463065

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) The molecule standing at platform one ...: Rapid glycopeptide synthesis is achieved with a heterobifunctional "molecular transporter" (see scheme), which interfaces two types of polymer platforms for combined chemical and enzymatic synthesis. This linker allows both chemoselective blotting and photoselective cleavage of the glycopeptides. Red: sugar residues; green: amino acid residues. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2534 / 2537

页数：4

共 28 条

[1] BUILDING-BLOCKS FOR SOLID-PHASE GLYCOPEPTIDE SYNTHESIS - 2-ACETAMIDO-2-DEOXY-BETA-D-GLYCOSIDES OF FMOCSEROH AND FMOCTHROH [J].