Protective immunity induced by live attenuated simian immunodeficiency virus

被引：115

作者：

Johnson, RP

Desrosiers, RC

机构：

[1] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Immunol, Southborough, MA 01772 USA

[2] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Microbiol, Southborough, MA 01772 USA

[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(98)80118-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.

引用

收藏

页码：436 / 443

页数：8

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