Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase

被引：5

作者：

Dar, P

Strassburger, D

Shaish, A

Levkovitz, H

Halperin, R

Harats, D

机构：

[1] Albert Einstein Coll Med, Dept Obstet & Gynecol, Div Reprod Genet, Bronx, NY 10467 USA

[2] Tel Aviv Univ, Sackler Fac Med, Dept Obstet & Gynecol, Assaf Harofeh Med Ctr, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Sheba Med Ctr, Inst Lipid & Atherosclerosis Res, IL-69978 Tel Aviv, Israel

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2001年 / 52卷 / 01期

关键词：

15-lipoxygenase; oxidized LDL; reproduction; spontaneous abortions; transgenic mice;

D O I：

10.1159/000052934

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

15-Lipoxygenase (15-LOX) is a lipid-oxidizing enzyme that is involved in cell cycle regulation. To evaluate the effect of 15-LOX on reproduction, we studied transgenic mice that overexpress 15-LOX. The transgene was introduced over the genetic background of the low density lipoprotein receptor deficient mice (LDL-R-/-) and reproduction was compared to LDL-R-/- mice. We found a lower pregnancy rate in the 15-LOX/LDL-R-/- mice as compared to the LDL-R-/- mice (62.74 vs. 79.1%, p < 0.01). Additionally, a remarkably higher number of resorptions per pregnancy was found in the 15-LOX/LDL-R-/- mice (16.7 vs. 3.27%, p < 0.001) and it was accompanied by a significantly higher activity of the 15-LOX enzyme in these resorptions as compared to other tissues. These findings may implicate a role for 15-LOX in the development of spontaneous abortions. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：18 / 21

页数：4

共 30 条

[1]

Bonet B, 1998, P SOC EXP BIOL MED, V217, P203

[2] OXIDIZED LOW-DENSITY LIPOPROTEINS INDUCE MESSENGER-RNA EXPRESSION AND RELEASE OF ENDOTHELIN FROM HUMAN AND PORCINE ENDOTHELIUM [J].