Regulation of Nav channels in sensory neurons

被引：58

作者：

Chahine, M ^{[1
]}

Ziane, R

Vijayaragavan, K

Okamura, Y

机构：

[1] Hop Laval, Res Ctr, Ste Foy, PQ G1V 4G5, Canada

[2] Univ Laval, Dept Med, Ste Foy, PQ G1K 7P4, Canada

[3] Okazaki Inst Integrat Biosci, Dept Dev Neurophysiol, Okazaki, Aichi, Japan

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 10期

基金：

日本学术振兴会; 加拿大健康研究院;

关键词：

D O I：

10.1016/j.tips.2005.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Voltage-gated Na+ channels have an essential role in the biophysical properties of nociceptive neurons. Factors that regulate Na+ channel function are of interest from both pathophysiological and therapeutic perspectives. Increasing evidence indicates that changes in expression or inappropriate modulation of these channels leads to electrical instability of the cell membrane and the inappropriate spontaneous activity that is observed following nerve injury, and that this might contribute to neuropathic pain. The role of Na+, channels in nociception depends on modulation by factors such as auxiliary beta-subunits, cytoskeletal proteins and the phosphorylation state of neurons. In this review we describe the modulation of Na-v channels on sensory neurons by auxiliary beta-subunits, protein kinases and cytoskeletal proteins.

引用

收藏

页码：496 / 502

页数：7

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