Oxidative stress and vascular damage in hypertension

被引：128

作者：

Berry, C ^{[1
]}

Brosnan, MJ ^{[1
]}

Fennell, J ^{[1
]}

Hamilton, CA ^{[1
]}

Dominiczak, AF ^{[1
]}

机构：

[1] Univ Glasgow, Dept Med & Therapeut, British Heart Fdn Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 02期

关键词：

D O I：

10.1097/00041552-200103000-00014

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Oxidative stress, a state of excessive reactive oxidative species activity, is associated with Vascular disease states such as hypertension. In this review, we discuss the recent advances in the field of reactive oxidative species-mediated vascular damage in hypertension. These include the identification of redox-sensitive tyrosine kinases, the characterization of enzymatic sources of superoxide production in human blood vessels, and their relationship with vascular damage in atherosclerosis and hypertension. Finally, recent developments in the search for strategies to attenuate vascular oxidative stress are reviewed, Curr Opin Nephrol Hypertens 10:247-255. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：247 / 255

页数：9

共 91 条

[31] Vascular superoxide production by NAD(P)H oxidase - Association with endothelial dysfunction and clinical risk factors [J].