Multiple sclerosis: current pathophysiological concepts

被引:156
作者
Wingerchuk, DM
Lucchinetti, CF
Noseworthy, JH
机构
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Neurol, Scottsdale, AZ USA
关键词
D O I
10.1038/labinvest.3780235
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological. and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a "primary oligodendrogliopathy" in demyelination and axonal injury; (e) the potential benefits of inflammation; Q the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.
引用
收藏
页码:263 / 281
页数:19
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