Xerogel optical sensor films for quantitative detection of nitroxyl

被引：38

作者：

Dobmeier, Kevin P. ^{[1
]}

Riccio, Daniel A. ^{[1
]}

Schoenfisch, Mark H. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ANALYTICAL CHEMISTRY | 2008年 / 80卷 / 04期

关键词：

D O I：

10.1021/ac702024t

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Xerogel sensing films were synthesized via sol-gel chemistry were used to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate ((MnTPPS)-T-III) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimedioxysilyl-terminated poly(amidoamine-organosilicon) dendrimers in the xerogel network. The selectivity of (MnTPPS)-T-III for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtiter plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor.

引用

页码：1247 / 1254

页数：8

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