Mobile elements in the evolution and spread of a multiple-drug resistance in staphylococci

被引:37
作者
Firth, N [1 ]
Skurray, RA [1 ]
机构
[1] Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia
基金
英国医学研究理事会;
关键词
D O I
10.1016/S1368-7646(98)80214-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since the introduction of antimicrobial chemotherapy, staphylococci have shown a remarkable propensity to develop drug resistance. As a result, strains have evolved that are resistant to most classes of clinically useful antimicrobial agents. The emergence of these multiply-drug-resistant strains is primarily due to the capture of pre-existent resistance genes. In combination with plasmids and gene transfer mechanisms, mobile genetic elements have been central to the acquisition and dissemination of this resistance. In particular they have played a significant role in the assembly of drug-resistance gene clusters in these multiply-resistant staphylococci.
引用
收藏
页码:49 / 58
页数:10
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