Mobile elements in the evolution and spread of a multiple-drug resistance in staphylococci

被引：37

作者：

Firth, N ^{[1
]}

Skurray, RA ^{[1
]}

机构：

[1] Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia

来源：

DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1368-7646(98)80214-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since the introduction of antimicrobial chemotherapy, staphylococci have shown a remarkable propensity to develop drug resistance. As a result, strains have evolved that are resistant to most classes of clinically useful antimicrobial agents. The emergence of these multiply-drug-resistant strains is primarily due to the capture of pre-existent resistance genes. In combination with plasmids and gene transfer mechanisms, mobile genetic elements have been central to the acquisition and dissemination of this resistance. In particular they have played a significant role in the assembly of drug-resistance gene clusters in these multiply-resistant staphylococci.

引用

收藏

页码：49 / 58

页数：10

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