Fear-related activity in subgenual anterior cingulate differs between men and women

被引：47

作者：

Butler, T ^{[1
]}

Pan, H

Epstein, J

Protopopescu, X

Tueschen, O

Goldstein, M

Cloitre, M

Yang, YH

Phelps, E

Gorman, J

Ledoux, J

Stern, E

Silbersweig, D

机构：

[1] Cornell Univ, Weill Med Coll, Funct Neuroimaging Lab, Ithaca, NY 14853 USA

[2] NYU, Dept Psychiat, Ctr Child Study, New York, NY 10016 USA

[3] NYU, Dept Psychol, New York, NY 10016 USA

[4] NYU, Ctr Neural Sci, New York, NY 10003 USA

[5] NIDA, MRI Phys Unit, Neuroimaging Res Branch, NIH, Washington, DC USA

[6] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

来源：

NEUROREPORT | 2005年 / 16卷 / 11期

关键词：

anticipatory anxiety; emotion; functional magnetic resonance imaging; instructed fear; sex; sex differences; ventromedial prefrontal cortex;

D O I：

10.1097/00001756-200508010-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

引用

页码：1233 / 1236

页数：4

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