MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?

被引：123

作者：

Clark, AR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst Rheumatol, London W6 8LH, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2003年 / 178卷 / 01期

关键词：

D O I：

10.1677/joe.0.1780005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore. the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.

引用

页码：5 / 12

页数：8

共 98 条

[61] Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38
Lasa, M
Brook, M
Saklatvala, J
Clark, AR
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (03) : 771 - 780
[62] Glucocorticoid-resistant asthma.
Loke T.K.
Sousa A.R.
Corrigan C.J.
Lee T.H.
[J]. Current Allergy and Asthma Reports, 2002, 2 (2) : 144 - 150
[63] ENDOGENOUS GLUCOCORTICOIDS REGULATE AN INDUCIBLE CYCLOOXYGENASE ENZYME
MASFERRER, JL
SEIBERT, K
ZWEIFEL, B
NEEDLEMAN, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) : 3917 - 3921
[64] Regulation of interleukin-β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
Miyazawa, K
Mori, A
Miyata, H
Akahane, M
Ajisawa, Y
Okudaira, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) : 24832 - 24838
[65] Transcriptional coactivator complexes
Näär, AM
Lemon, BD
Tjian, R
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 : 475 - 501
[66] Molecular mechanisms of glucocorticoid action: what is important?
Newton, R
[J]. THORAX, 2000, 55 (07) : 603 - 613
[67] Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA
Newton, R
Seybold, J
Kuitert, LME
Bergmann, M
Barnes, PJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (48) : 32312 - 32321
[68] The p38 signal transduction pathway - Activation and function
Ono, K
Han, JH
[J]. CELLULAR SIGNALLING, 2000, 12 (01) : 1 - 13
[69] Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability
Pagès, G
Berra, E
Milanini, J
Levy, AP
Pouysségur, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (34) : 26484 - 26491
[70] Oxidative stress, transcription factors and chromatin remodelling in lung inflammation
Rahman, I
[J]. BIOCHEMICAL PHARMACOLOGY, 2002, 64 (5-6) : 935 - 942

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