Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton

被引:439
作者
Faul, Christian
Asanuma, Katsuhiko
Yanagida-Asanuma, Etsuko
Kim, Kwanghee
Mundel, Peter [1 ]
机构
[1] CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[2] Juntendo Univ, Sch Med, Div Nephrol, Tokyo 1138421, Japan
关键词
D O I
10.1016/j.tcb.2007.06.006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte foot processes form a characteristic interdigitating pattern with foot processes of neighboring podocytes, leaving in between the filtration slits that are bridged by the glomerular slit diaphragm. The highly dynamic foot processes contain an actin-based contractile apparatus comparable to that of smooth muscle cells or pericytes. Mutations affecting several podocyte proteins lead to rearrangement of the actin cytoskeleton, disruption of the filtration barrier and subsequent renal disease. The fact that the dynamic regulation of the podocyte cytoskeleton is vital to kidney function has led to podocytes emerging as an excellent model system for studying actin cytoskeleton dynamics in a physiological context.
引用
收藏
页码:428 / 437
页数:10
相关论文
共 83 条
[81]   The potential role of podoplanin in tumour invasion [J].
Wicki, A. ;
Christofori, G. .
BRITISH JOURNAL OF CANCER, 2007, 96 (01) :1-5
[82]   A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis [J].
Winn, MP ;
Conlon, PJ ;
Lynn, KL ;
Farrington, MK ;
Creazzo, T ;
Hawkins, AF ;
Daskalakis, N ;
Kwan, SY ;
Ebersviller, S ;
Burchette, JL ;
Pericak-Vance, MA ;
Howel, DN ;
Vance, JM ;
Rosenberg, PB .
SCIENCE, 2005, 308 (5729) :1801-1804
[83]   Formation and phosphorylation of the PINCH-1-integrin linked kinase-α-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival [J].
Yang, YQ ;
Guo, LD ;
Blattner, SM ;
Mundel, P ;
Kretzler, M ;
Wu, CY .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (07) :1966-1976