Solid-phase organic reactions: A review of the recent literature

被引:553
作者
Hermkens, PHH [1 ]
Ottenheijm, HCJ [1 ]
Rees, D [1 ]
机构
[1] ORGANON RES LABS LTD,SCI DEV GRP,NEWHOUSE ML1 5SH,LANARK,SCOTLAND
关键词
D O I
10.1016/0040-4020(96)00216-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Combinatorial chemistry has emerged as a powerful new technology for chemists to synthesise large numbers of compounds for biological evaluation. One of the techniques used in combinatorial chemistry is polymer supported or ''solid-phase'' organic synthesis. This article reviews the main chemical reactions reported between 1992-October 1995 using solid-phase support, focusing upon those suitable for synthesising small molecules. The reactions are presented in graphical format in a table according to reaction types. Examples presented include amide bond formation, aromatic substitutions, condensations, cycloadditions, diazotisation, enzymatic coupling, use of Grignard reagents, Michael additions, multiple component reactions, nucleophilic substitution, olefination, oxidations, protection/deprotection, reduction, immobilisation and cleavage. Finally, the information presented is evaluated briefly and some trends are discussed.
引用
收藏
页码:4527 / 4554
页数:28
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