Bisphenol-A and chlorinated derivatives in adipose tissue of women

被引：247

作者：

Fernandez, M. F. ^{[1
]}

Arrebola, J. P.

Taoufiki, J.

Navalon, A.

Ballesteros, O.

Pulgar, R.

Vilchez, J. L.

Olea, N.

机构：

[1] Univ Granada, San Cecilio Univ Hosp, Lab Med Invest, E-18071 Granada, Spain

[2] Univ Granada, Dept Analyt Chem, Res Grp Analyt Chem & Life Sci, E-18071 Granada, Spain

来源：

REPRODUCTIVE TOXICOLOGY | 2007年 / 24卷 / 02期

关键词：

bisphenol-A; bisphenol-A chlorinated derivatives; adipose tissue; women exposure;

D O I：

10.1016/j.reprotox.2007.06.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bisphenol-A (BPA) and chlorinated derivatives (Cl(x)BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in I I out of 20 samples (55%). Among Cl(2)BPA, Cl(2)BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean +/- S.D. of BPA, monochloro-BPA (CIBPA), dichloro-BPA (Cl(2)BPA), and trichloro-BPA (Cl(3)BPA) were 5.83 +/- 3.48, 3.05 +/- 0.28, 9.21 +/- 9.26, and 0.74 +/- 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl(4)BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl(x)BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure. (C) 2007 Published by Elsevier Inc.

引用

页码：259 / 264

页数：6

共 53 条

[41] Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels [J].

Takeuchi, T ;

Tsutsumi, O .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (01) :76-78

[42]

THOMPSON M, 1994, ANALYST, V119, P2363

[43] Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure [J].

Welshons, Wade V. ;

Nagel, Susan C. ;

Saal, Frederick S. vom .

ENDOCRINOLOGY, 2006, 147 (06) :S56-S69

[44] Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles [J].

Wong, KO ;

Leo, LW ;

Seah, HL .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2005, 22 (03) :280-288

[45]

*WWF, 2000, BISPH KNOWN END DISR

[46] Quantities of bisphenol A leached from plastic waste samples [J].

Yamamoto, T ;

Yasuhara, A .

CHEMOSPHERE, 1999, 38 (11) :2569-2576

[47] Chlorination of bisphenol A in aqueous media: formation of chlorinated bisphenol A congeners and degradation to chlorinated phenolic compounds [J].

Yamamoto, T ;

Yasuhara, A .

CHEMOSPHERE, 2002, 46 (08) :1215-1223

[48] Bisphenol A in hazardous waste landfill leachates [J].

Yamamoto, T ;

Yasuhara, A ;

Shiraishi, H ;

Nakasugi, O .

CHEMOSPHERE, 2001, 42 (04) :415-418

[49]

Yamashita H, 2002, IEEE T DIELECT EL IN, V9, P2

[50] Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry [J].

Ye, XY ;

Kuklenyik, Z ;

Needham, LL ;

Calafat, AM .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2006, 831 (1-2) :110-115

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