Hybrid nanoparticles for magnetic resonance imaging of target-specific viral gene delivery

被引:67
作者
Huh, Yong-Min
Lee, Eun-Sook
Lee, Jae-Hyun
Jun, Young-Wook
Kim, Pyung-Hwan
Yun, Chae-Ok
Kim, Joo-Hang
Suh, Jin-Suck [1 ]
Cheon, Jinwoo
机构
[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea
[2] Yonsei Univ, Dept Chem, Seoul 120749, South Korea
[3] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Inst Canc Res, Seoul 120752, South Korea
关键词
D O I
10.1002/adma.200701952
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Hybrid nanoparticles with multi-functional capabilities of targeted infection, magnetic resonance (MR) imaging, and gene delivery are developed by fusing virus and MnMEIO magnetic nanoparticles. Their successful utilizations for in vitro target-specific MR imaging and enhanced green fluorescent protein (eGFP) gene delivery into CAR-positive cells are demonstrated.
引用
收藏
页码:3109 / +
页数:5
相关论文
共 20 条
[1]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[2]   Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid [J].
Anderson, Elizabeth A. ;
Isaacman, Steven ;
Peabody, David S. ;
Wang, Edwin Y. ;
Canary, James W. ;
Kirshenbaum, Kent .
NANO LETTERS, 2006, 6 (06) :1160-1164
[3]   Cellular magnetic resonance imaging: current status and future prospects [J].
Arbab, Ali S. ;
Liu, Wei ;
Frank, Joseph A. .
EXPERT REVIEW OF MEDICAL DEVICES, 2006, 3 (04) :427-439
[4]   MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles [J].
Artemov, D ;
Mori, N ;
Okollie, B ;
Bhujwalla, ZM .
MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (03) :403-408
[5]   Adenovirus vectors for gene delivery [J].
Benihoud, K ;
Yeh, P ;
Perricaudet, M .
CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (05) :440-447
[6]   Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 [J].
Bergelson, JM ;
Cunningham, JA ;
Droguett, G ;
KurtJones, EA ;
Krithivas, A ;
Hong, JS ;
Horwitz, MS ;
Crowell, RL ;
Finberg, RW .
SCIENCE, 1997, 275 (5304) :1320-1323
[7]   Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells [J].
Bulte, JWM ;
Douglas, T ;
Witwer, B ;
Zhang, SC ;
Strable, E ;
Lewis, BK ;
Zywicke, H ;
Miller, B ;
van Gelderen, P ;
Moskowitz, BM ;
Duncan, ID ;
Frank, JA .
NATURE BIOTECHNOLOGY, 2001, 19 (12) :1141-1147
[8]   Quantum dot encapsulation in viral capsids [J].
Dixit, Suraj K. ;
Goicochea, Nancy L. ;
Daniel, Marie-Christine ;
Murali, Ayaluru ;
Bronstein, Lyudmila ;
De, Mrinmoy ;
Stein, Barry ;
Rotello, Vincent M. ;
Kao, C. Cheng ;
Dragnea, Bogdan .
NANO LETTERS, 2006, 6 (09) :1993-1999
[9]   Covalently linked au nanoparticles to a viral vector: Potential for combined photothermal and gene cancer therapy [J].
Everts, M ;
Saini, V ;
Leddon, JL ;
Kok, RJ ;
Stoff-Khalili, M ;
Preuss, MA ;
Millican, CL ;
Perkins, G ;
Brown, JM ;
Bagaria, H ;
Nikles, DE ;
Johnson, DT ;
Zharov, VP ;
Curiel, DT .
NANO LETTERS, 2006, 6 (04) :587-591
[10]  
HERMANSON GT, 1996, BIOCONJUGATE TECHNIQ, P235