Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective

被引：126

作者：

Pullikuth, Ashok K.

Catling, Andrew D.

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA

来源：

CELLULAR SIGNALLING | 2007年 / 19卷 / 08期

关键词：

MP1; p14; scaffold; actin; microtubule dynamics; calpains; rho; PAK; MEK; ERK; ste5; cell migration;

D O I：

10.1016/j.cellsig.2007.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell migration is critical for many physiological processes and is often misregulated in developmental disorders and pathological conditions including cancer and neurodegeneration. MAPK signaling and the Rho family of proteins are known regulators of cell migration that exert their influence on cellular cytoskeleton during cell adhesion and migration. Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration. (c) 2007 Elsevier Inc. All rights reserved.

引用

收藏

页码：1621 / 1632

页数：12

相关论文

共 231 条

[21] A novel role for FAK as a protease-targeting adaptor protein: Regulation by p42 ERK and Src [J].

Carragher, NO ;

Westhoff, MA ;

Fincham, VJ ;

Schaller, MD ;

Frame, MC .

CURRENT BIOLOGY, 2003, 13 (16) :1442-1450

[22] Cleavage of focal adhesion kinase by different proteases during Src-reguIated transformation and apoptosis - Distinct roles for calpain and caspases [J].

Carragher, NO ;

Fincham, VJ ;

Riley, D ;

Frame, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (06) :4270-4275

[23] Integrin trafficking and the control of cell migration [J].

Caswell, PT ;

Norman, JC .

TRAFFIC, 2006, 7 (01) :14-21

[24] Rab8 regulates the actin-based movement of melanosomes [J].

Chabrillat, ML ;

Wilhelm, C ;

Wasmeier, C ;

Sviderskaya, EV ;

Louvard, D ;

Coudrier, E .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (04) :1640-1650

[25] C-SRC REGULATES THE SIMULTANEOUS REARRANGEMENT OF ACTIN CYTOSKELETON, P190RHOGAP, AND P120RASGAP FOLLOWING EPIDERMAL GROWTH-FACTOR STIMULATION [J].

CHANG, JH ;

GILL, S ;

SETTLEMAN, J ;

PARSONS, SJ .

JOURNAL OF CELL BIOLOGY, 1995, 130 (02) :355-368

[26]

CHANG JH, 1993, ONCOGENE, V8, P959

[27] Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling [J].

Channavajhala, PL ;

Wu, LY ;

Cuozzo, JW ;

Hall, JP ;

Liu, W ;

Lin, LL ;

Zhang, YH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) :47089-47097

[28] Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells [J].

Chen, BH ;

Tzen, JTC ;

Bresnick, AR ;

Chen, HC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) :33857-33863

[29]

CHEN QM, 1994, J BIOL CHEM, V269, P26602

[30] Integrin-mediated activation of mitogen activated protein (MAP) or extracellular signal-related kinase kinase (MEK) and kinase is independent of Ras [J].

Chen, QM ;

Lin, TH ;

Der, CJ ;

Juliano, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :18122-18127

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