Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective

被引：126

作者：

Pullikuth, Ashok K.

Catling, Andrew D.

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70112 USA

来源：

CELLULAR SIGNALLING | 2007年 / 19卷 / 08期

关键词：

MP1; p14; scaffold; actin; microtubule dynamics; calpains; rho; PAK; MEK; ERK; ste5; cell migration;

D O I：

10.1016/j.cellsig.2007.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell migration is critical for many physiological processes and is often misregulated in developmental disorders and pathological conditions including cancer and neurodegeneration. MAPK signaling and the Rho family of proteins are known regulators of cell migration that exert their influence on cellular cytoskeleton during cell adhesion and migration. Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1621 / 1632

页数：12

共 231 条

[51] Caveolae internalization regulates integrin-dependent signaling pathways [J].