Study of solution equilibria between aluminum(III) ion and ofloxacin

The complex formation equilibria between aluminium(III) ion and ofloxacin in 0.1 mol l(-1) ionic medium at 298 K were studied by glass electrode pH-metric and UV spectrophotometric measurements. Within ofloxacin to aluminium mole ratio ranging from 2:1 to 25:1 and in pH interval from 2.5 to 10.5, the obtained experimental results were explained by the formation of the following complexes: Al(oflo) (log beta(1,1,1) = 15.93 +/- 0.03), Al(oflo)(2) (log beta(1,2,0) = 14.84 +/- 0.07), Al(oflo) (log beta(1,1,0) = 10.20 +/- 0.04) as well as several other mixed and pure hydrolytic complexes. The structure and mechanism of the formation of the complexes and their possible implications on aluminum toxicity were discussed. (C) 1999 Elsevier Science B.V. AU rights reserved.